Cerebral N-acetylaspartate is low in patients with multiple sclerosis and abnormal visual evoked potentials

TitleCerebral N-acetylaspartate is low in patients with multiple sclerosis and abnormal visual evoked potentials
Publication TypeJournal Article
1998
AuthorsHeide AC, Kraft GH, Slimp JC, Gardner JC, Posse S, Serafini S, Bowen JD, Richards TL
JournalAmerican Journal of Neuroradiology
Volume19
Issue6
Pagination1047-54

PURPOSE: Our purpose was to compare cerebral proton MR metabolite changes in patients with multiple sclerosis (MS) and abnormal visual evoked potentials (VEPs) with those in MS patients with normal VEPs. METHODS: Seventeen subjects with clinically definite MS were studied with VEPs and MR spectroscopic imaging. Proton MR metabolites were measured using a fast spectroscopic imaging technique called proton echo-planar spectroscopic imaging (PEPSI). Kurtzke's Expanded Disability Status Scale (EDSS) score was also ascertained for each subject to obtain a clinical rating. Twelve regions of interest within the visual pathway of the cerebrum were evaluated for levels of N-acetylaspartate (NAA), choline, creatine, and the presence or absence of MR-detectable lesions. RESULTS: PEPSI NAA values (water-normalized, CSF-corrected) were significantly lower in MS subjects with abnormal VEPs than in subjects with normal VEPs. MR-detectable lesion fractions and EDSS scores were also significantly different between the two VEP groups, but NAA comparison had a P value 100 times less than either of these measures. CONCLUSION: In patients with MS, NAA measurements in the optic pathways of the brain were sensitive to VEP abnormalities. NAA was more sensitive to VEP changes than were choline, creatine, MR-detectable lesions, and EDSS score.

http://www.ncbi.nlm.nih.gov/pubmed/9672010

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