Discordant functional and inflammatory parameters in multiple sclerosis patients after autologous haematopoietic stem cell transplantation.

TitleDiscordant functional and inflammatory parameters in multiple sclerosis patients after autologous haematopoietic stem cell transplantation.
Publication TypeJournal Article
2004
AuthorsHealey KM, Pavletic S, Al-Omaishi J, Leuschen PM, Pirruccello SJ, Filipi ML, Enke C, Ursick M M, Hahn F, Bowen JD, Nash RA
JournalMultiple Sclerosis
Volume10
Issue3
Pagination284-9
Date Published2004 Jun
ISSN1352-4585
Adult, Disability Evaluation, Female, Hematopoietic Stem Cell Transplantation, Humans, Immunoglobulin G, Male, Middle Aged, Multiple Sclerosis, Neurologic Examination, Pilot Projects, Treatment Outcome

This article describes outcomes in four patients with advanced multiple sclerosis up to two years after autologous haematopoietic stem cell transplantation using a total-body irradiation-based preparative regimen. MRI and CSF analyses demonstrated clear suppression of the inflammatory processes. The results demonstrate however, a dissociation of inflammation parameters and functional disability findings raising questions about optimal future stem cell transplantation strategies for this disease.

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