Discordant functional and inflammatory parameters in multiple sclerosis patients after autologous haematopoietic stem cell transplantation.
| Title | Discordant functional and inflammatory parameters in multiple sclerosis patients after autologous haematopoietic stem cell transplantation. |
| Publication Type | Journal Article |
| 2004 | |
| Authors | Healey KM, Pavletic S, Al-Omaishi J, Leuschen PM, Pirruccello SJ, Filipi ML, Enke C, Ursick M M, Hahn F, Bowen JD, Nash RA |
| Journal | Multiple Sclerosis |
| Volume | 10 |
| Issue | 3 |
| Pagination | 284-9 |
| Date Published | 2004 Jun |
| ISSN | 1352-4585 |
| Adult, Disability Evaluation, Female, Hematopoietic Stem Cell Transplantation, Humans, Immunoglobulin G, Male, Middle Aged, Multiple Sclerosis, Neurologic Examination, Pilot Projects, Treatment Outcome | |
This article describes outcomes in four patients with advanced multiple sclerosis up to two years after autologous haematopoietic stem cell transplantation using a total-body irradiation-based preparative regimen. MRI and CSF analyses demonstrated clear suppression of the inflammatory processes. The results demonstrate however, a dissociation of inflammation parameters and functional disability findings raising questions about optimal future stem cell transplantation strategies for this disease. |
