Approved and future pharmacotherapy for multiple sclerosis.

TitleApproved and future pharmacotherapy for multiple sclerosis.
Publication TypeJournal Article
2002
AuthorsStüve O, Cree BC, von Büdingen H-C, Yousef S, Bowen JD, Genain CP, Hauser SL, Steinman L, Zamvil SS
JournalNeurologist
Volume8
Issue5
Pagination290-301
Date Published2002 Sep
ISSN1074-7931

BACKGROUND: Pharmacotherapy for relapsing-remitting multiple sclerosis (MS) advanced with the demonstration that interferon beta and glatiramer acetate improve the clinical course of this disease. Mitoxantrone is the first drug approved by the Food and Drug Administration for treatment of secondary progressive MS. Despite this progress, the agents presently available are only partially effective, are difficult to administer, and may have significant side effects. Several orally administered immunomodulatory agents are presently being evaluated for treatment of MS. One class of drugs, HMG CoA inhibitors (statins), is safe and well-tolerated and could become another mainstay of MS therapy. REVIEW SUMMARY: This article reviews the clinical evidence for approved MS therapies and discusses their mechanisms of action. Furthermore, the clinical and laboratory data suggesting a potential role for statins in MS therapy are discussed. CONCLUSIONS: Although treatment with interferon beta, glatiramer acetate, and mitoxantrone, the approved therapies, provide important treatment options for patients with relapsing-remitting MS and secondary progressive MS, the potential benefits of other medications, including statins, should be explored in controlled clinical trials.

http://www.ncbi.nlm.nih.gov/pubmed/12803676

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